达州中医药职业学院;达州市达川区人民医院第三人民医院;
癌症死亡率居高不下,但传统的治疗方法效果不佳,耐药性,毒副作用等进一步限制了癌症的治疗。靶向药物递送系统,尤其是靶向特定细胞器与传统药物相比具有显著优势:它们可以极大地帮助减少药物用量、改善治疗靶点、避免多药耐药、避免复发和避免副作用。其中,高尔基体的功能与肿瘤的发生,增殖,转移密切相关,是一种潜在的抗肿瘤靶点。目前,高尔基体靶向转运的机制尚不清楚。此外,针对单个细胞器的靶向药物可能并不理想。但是,在未来的肿瘤治疗中,高尔基体靶向策略将发挥不可替代的作用。本综述系统地总结了目前报道的高尔基体靶向递送系统,介绍了高尔基体与肿瘤的关系及靶向机制,期望对未来高尔基体靶向递送系统的升级提供参考。
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基本信息:
DOI:
中图分类号:R730.5
引用信息:
[1]吴诗情,燕雄.高尔基体靶向递送系统用于癌症的研究进展[J].贵州医药,2025,49(04):537-542.
基金信息: