[1] Warnakulasuriya S.Global epidemiology of oral and oropharyngeal cancer [J].Oral Oncol,2009,45(4-5):309-316.

[2] Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018:Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].CA Cancer J Clin,2018,68(6):394-424.

[3] Dhanuthai K,Rojanawatsirivej S,Thosaporn W,et al.Oral cancer:A multicenter study [J].Med Oral Patol Oral Cir Bucal,2018,23(1):e23-e29.

[4] Ng JH,Iyer NG,Tan MH,et al.Changing epidemiology of oral squamous cell carcinoma of the tongue:A global study [J].Head Neck,2017,39(2):297-304.

[5] Lodish H,Berk A,ZipurskySL,et al.Molecular cell biology.4th edition.[M].New York:W.H.Freeman and Company,2000.

[6] Ng LF,Kaur P,Bunnag N,et al.Wnt signaling in disease [J].Cells,2019,8(8).

[7] Taciak B,Pruszynska I,Kiraga L,et al.Wnt signaling pathway in development and cancer [J].J Physiol Pharmacol,2018,69(2).

[8] Li L,Liu HC,Wang C,et al.Overexpression of β-catenin induces cisplatin resistance in oral squamous cell carcinoma [J].Biomed Res Int,2016,2016(5378567.

[9] Kormish JD,Sinner D,Zorn AM.Interactions between sox factors and wnt/beta-catenin signaling in development and disease [J].Dev Dyn,2010,239(1):56-68.

[10] Xie SL,Fan S,Zhang SY,et al.Sox8 regulates cancer stem-like properties and cisplatin-induced emt in tongue squamous cell carcinoma by acting on the wnt/β-catenin pathway [J].International journal of cancer,2018,142(6):1252-1265.

[11] Si W,Shen J,Zheng H,et al.The role and mechanisms of action of micrornas in cancer drug resistance [J].Clin Epigenetics,2019,11(1):25.

[12] Thompson JJ,Williams CS.Protein phosphatase 2a in the regulation of wnt signaling,stem cells,and cancer [J].Genes (Basel),2018,9(3).

[13] Zhuang Z,Hu F,Hu J,et al.Microrna-218 promotes cisplatin resistance in oral cancer via the ppp2r5a/wnt signaling pathway [J].Oncology reports,2017,38(4):2051-2061.

[14] Yan Q,Su Y,Zhou Y,et al.[interleukin-23 strengthens the anti-apoptotic and drug resistance of human tongue squamous cell carcinoma through the wingless-related integration site/β-catenin pathway] [J].West China journal of stomatology,2015,33(3):249-254.

[15] Vander Broek R,Mohan S,Eytan DF,et al.The pi3k/akt/mtor axis in head and neck cancer:Functions,aberrations,cross-talk,and therapies [J].Oral Dis,2015,21(7):815-825.

[16] Marquard FE,Jucker M.Pi3k/akt/mtor signaling as a molecular target in head and neck cancer [J].Biochem Pharmacol,2020,172(113729.

[17] Yang J,Nie J,Ma X,et al.Targeting pi3k in cancer:Mechanisms and advances in clinical trials [J].Molecular cancer,2019,18(1):26.

[18] Chen Y,Hou Q,Yan W,et al.Pik3ca is critical for the proliferation,invasiveness,and drug resistance of human tongue carcinoma cells [J].Oncol Res,2011,19(12):563-571.

[19] Lu Z,Guo H,Lin Y,et al.Effects of pten gene silencing on invasion and emt in oral squamous carcinoma tca8113 cells [J].Journal of oral pathology & medicine :official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,2017,46(1):31-38.

[20] Baghaei F,Abdollahi A,Mohammadpour H,et al.Pten and mir-26b:Promising prognostic biomarkers in initiation and progression of oral squamous cell carcinoma [J].Journal of oral pathology & medicine :official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,2019,48(1):31-35.

[21] Zheng X,Li J,Peng C,et al.Microrna-24 induces cisplatin resistance by targeting pten in human tongue squamous cell carcinoma [J].Oral Oncol,2015,51(11):998-1003.

[22] Zheng G ,Jia X,C,P,et al.The mir-491-3p/mtorc2/foxo1 regulatory loop modulates chemo-sensitivity in human tongue cancer.[J].Oncotarget,2015,6(9):6931‐6943.(

[23] Hung C,Chien C,W C.P22phox confers resistance to cisplatin,by blocking its entry into the nucleus [J].Oncotarget,2015.Feb,6(6):4110–4125(

[24] Xia Y,Shen S,Verma IM.Nf-kappab,an active player in human cancers [J].Cancer Immunol Res,2014,2(9):823-830.

[25] Pires BRB,Silva R,Ferreira GM,et al.Nf-kappab:Two sides of the same coin [J].Genes (Basel),2018,9(1).

[26] Zheng G,Zhang Z,Liu H,et al.Hsp27-mediated extracellular and intracellular signaling pathways synergistically confer chemoresistance in squamous cell carcinoma of tongue [J].Clinical cancer research :an official journal of the American Association for Cancer Research,2018,24(5):1163-1175.

[27] Shankar E,Weis MC,Avva J,et al.Complex systems biology approach in connecting pi3k-akt and nf-kappab pathways in prostate cancer [J].Cells,2019,8(3).

[28] Peng B,Gu Y,Xiong Y,et al.Microarray-assisted pathway analysis identifies mt1x & nfκb as mediators of tcrp1-associated resistance to cisplatin in oral squamous cell carcinoma [J].PloS one,2012,7(12):e51413.

[29] Gu Y,Liu H,Kong F,et al.Mir-22/kat6b axis is a chemotherapeutic determiner via regulation of pi3k-akt-nf-kb pathway in tongue squamous cell carcinoma [J].Journal of experimental & clinical cancer research :CR,2018,37(1):164.

[30] Denys H,Braems G,Lambein K ea.The extracellular matrix regulates cancer progression and therapy response:Implications for prognosis and treatment [J].Curr Pharm Des,2009,15(12):1373-84.(12.

[31] Nakagawa Y,Nakayama H,Nagata M,et al.Overexpression of fibronectin confers cell adhesion-mediated drug resistance (cam-dr) against 5-fu in oral squamous cell carcinoma cells [J].International journal of oncology,2014,44(4):1376-1384.

[32] O'Shea JJ,Holland SM,Staudt LM.Jaks and stats in immunity,immunodeficiency,and cancer [J].N Engl J Med,2013,368(2):161-170.

[33] O'Shea JJ,Schwartz DM,Villarino AV,et al.The jak-stat pathway:Impact on human disease and therapeutic intervention [J].Annu Rev Med,2015,66(311-328.

[34] Zhou X,Ren Y,Liu A,et al.Wp1066 sensitizes oral squamous cell carcinoma cells to cisplatin by targeting stat3/mir-21 axis [J].Sci Rep,2014,4(7461.

[35] Maji S,Shriwas O,Samal SK,et al.Stat3- and gsk3beta-mediated mcl-1 regulation modulates tpf resistance in oral squamous cell carcinoma [J].Carcinogenesis,2019,40(1):173-183.